Sperm surface proteomics: from protein lists to biological function

Structural Proteomics: Inferring Function from Protein Structure

We describe how knowledge of three dimensional protein structure can add to the understanding of as yet functionally unannotated protein sequences. Structure determination may reveal that the new protein shares structural similarity with a previously observed structure or that it is a novel fold. The manner in which structure can be used to suggest the function of a protein will depend on the n...

Proteomics of spermatogenesis: from protein lists to understanding the regulation of male fertility and infertility.

Proteomic technologies have undergone significant development in recent years, which has led to extensive advances in protein research. Currently, proteomic approaches have been applied to many scientific areas, including basic research, various disease and malignant tumour diagnostics, biomarker discovery and other therapeutic applications. In addition, proteomics-driven research articles exam...

Proteomics: from single molecules to biological pathways

The conventional reductionist approach to cardiovascular research investigates individual candidate factors or linear signalling pathways but ignores more complex interactions in biological systems. The advent of molecular profiling technologies that focus on a global characterization of whole complements allows an exploration of the interconnectivity of pathways during pathophysiologically rel...

The Promyelocytic Leukemia Protein, PML, and Its Biological Function

Fungal proteomics: from identification to function.

Some fungi cause disease in humans and plants, while others have demonstrable potential for the control of insect pests. In addition, fungi are also a rich reservoir of therapeutic metabolites and industrially useful enzymes. Detailed analysis of fungal biochemistry is now enabled by multiple technologies including protein mass spectrometry, genome and transcriptome sequencing and advances in b...